Pesquisa | BVS Violência e Saúde

1.

Defining the Teratoma as a Model for Multi-lineage Human Development.

McDonald, Daniella; Wu, Yan; Dailamy, Amir; Tat, Justin; Parekh, Udit; Zhao, Dongxin; Hu, Michael; Tipps, Ann; Zhang, Kun; Mali, Prashant.

Cell ; 183(5): 1402-1419.e18, 2020 11 25.

Artigo em Inglês | MEDLINE | ID: mdl-33152263

2.

Humanizing Transcriptome Engineering.

Mali, Prashant.

Cell ; 178(1): 8-9, 2019 06 27.

Artigo em Inglês | MEDLINE | ID: mdl-31251918

3.

Scalable Functional Assays for the Interpretation of Human Genetic Variation.

Tabet, Daniel; Parikh, Victoria; Mali, Prashant; Roth, Frederick P; Claussnitzer, Melina.

Annu Rev Genet ; 56: 441-465, 2022 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-36055970

4.

Insulin-regulated serine and lipid metabolism drive peripheral neuropathy.

Handzlik, Michal K; Gengatharan, Jivani M; Frizzi, Katie E; McGregor, Grace H; Martino, Cameron; Rahman, Gibraan; Gonzalez, Antonio; Moreno, Ana M; Green, Courtney R; Guernsey, Lucie S; Lin, Terry; Tseng, Patrick; Ideguchi, Yoichiro; Fallon, Regis J; Chaix, Amandine; Panda, Satchidananda; Mali, Prashant; Wallace, Martina; Knight, Rob; Gantner, Marin L; Calcutt, Nigel A; Metallo, Christian M.

Nature ; 614(7946): 118-124, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36697822

5.

Transcriptional control of leukemogenesis by the chromatin reader SGF29.

Barbosa, Karina; Deshpande, Anagha; Perales, Marlenne; Xiang, Ping; Murad, Rabi; Pramod, Akula Bala; Minkina, Anna; Robertson, Neil; Schischlik, Fiorella; Lei, Xue; Sun, Younguk; Brown, Adam; Amend, Diana; Jeremias, Irmela; Doench, John G; Humphries, R Keith; Ruppin, Eytan; Shendure, Jay; Mali, Prashant; Adams, Peter D; Deshpande, Aniruddha J.

Blood ; 143(8): 697-712, 2024 Feb 22.

Artigo em Inglês | MEDLINE | ID: mdl-38048593

6.

Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis.

Zhao, Dongxin; Badur, Mehmet G; Luebeck, Jens; Magaña, Jose H; Birmingham, Amanda; Sasik, Roman; Ahn, Christopher S; Ideker, Trey; Metallo, Christian M; Mali, Prashant.

Mol Cell ; 69(4): 699-708.e7, 2018 02 15.

Artigo em Inglês | MEDLINE | ID: mdl-29452643

7.

Defining the activity of pro-reparative extracellular vesicles in wound healing based on miRNA payloads and cell type-specific lineage mapping.

Park, Dong Jun; Choi, Wooil; Sayeed, Sakeef; Dorschner, Robert A; Rainaldi, Joseph; Ho, Kayla; Kezios, Jenny; Nolan, John P; Mali, Prashant; Costantini, Todd; Eliceiri, Brian P.

Mol Ther ; 2024 Feb 19.

Artigo em Inglês | MEDLINE | ID: mdl-38379282

8.

Whole-genome CRISPR screening identifies PI3K/AKT as a downstream component of the oncogenic GNAQ-focal adhesion kinase signaling circuitry.

Arang, Nadia; Lubrano, Simone; Rigiracciolo, Damiano Cosimo; Nachmanson, Daniela; Lippman, Scott M; Mali, Prashant; Harismendy, Olivier; Gutkind, J Silvio.

J Biol Chem ; 299(2): 102866, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36596361

9.

RNA editing: Expanding the potential of RNA therapeutics.

Booth, Brian J; Nourreddine, Sami; Katrekar, Dhruva; Savva, Yiannis; Bose, Debojit; Long, Thomas J; Huss, David J; Mali, Prashant.

Mol Ther ; 31(6): 1533-1549, 2023 06 07.

Artigo em Inglês | MEDLINE | ID: mdl-36620962

10.

Methods for recruiting endogenous and exogenous ADAR enzymes for site-specific RNA editing.

Xiang, Yichen; Katrekar, Dhruva; Mali, Prashant.

Methods ; 205: 158-166, 2022 09.

Artigo em Inglês | MEDLINE | ID: mdl-35779766

11.

In vivo RNA editing of point mutations via RNA-guided adenosine deaminases.

Katrekar, Dhruva; Chen, Genghao; Meluzzi, Dario; Ganesh, Ashwin; Worlikar, Atharv; Shih, Yu-Ru; Varghese, Shyni; Mali, Prashant.

Nat Methods ; 16(3): 239-242, 2019 03.

Artigo em Inglês | MEDLINE | ID: mdl-30737497

12.

Rapidly evolving homing CRISPR barcodes.

Kalhor, Reza; Mali, Prashant; Church, George M.

Nat Methods ; 14(2): 195-200, 2017 02.

Artigo em Inglês | MEDLINE | ID: mdl-27918539

13.

Genetic interaction mapping in mammalian cells using CRISPR interference.

Du, Dan; Roguev, Assen; Gordon, David E; Chen, Meng; Chen, Si-Han; Shales, Michael; Shen, John Paul; Ideker, Trey; Mali, Prashant; Qi, Lei S; Krogan, Nevan J.

Nat Methods ; 14(6): 577-580, 2017 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-28481362

14.

Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.

Shen, John Paul; Zhao, Dongxin; Sasik, Roman; Luebeck, Jens; Birmingham, Amanda; Bojorquez-Gomez, Ana; Licon, Katherine; Klepper, Kristin; Pekin, Daniel; Beckett, Alex N; Sanchez, Kyle Salinas; Thomas, Alex; Kuo, Chih-Chung; Du, Dan; Roguev, Assen; Lewis, Nathan E; Chang, Aaron N; Kreisberg, Jason F; Krogan, Nevan; Qi, Lei; Ideker, Trey; Mali, Prashant.

Nat Methods ; 14(6): 573-576, 2017 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-28319113

15.

RNA-Guided Adenosine Deaminases: Advances and Challenges for Therapeutic RNA Editing.

Chen, Genghao; Katrekar, Dhruva; Mali, Prashant.

Biochemistry ; 58(15): 1947-1957, 2019 04 16.

Artigo em Inglês | MEDLINE | ID: mdl-30943016

16.

A multifunctional AAV-CRISPR-Cas9 and its host response.

Chew, Wei Leong; Tabebordbar, Mohammadsharif; Cheng, Jason K W; Mali, Prashant; Wu, Elizabeth Y; Ng, Alex H M; Zhu, Kexian; Wagers, Amy J; Church, George M.

Nat Methods ; 13(10): 868-74, 2016 10.

Artigo em Inglês | MEDLINE | ID: mdl-27595405

17.

In Situ Gene Therapy via AAV-CRISPR-Cas9-Mediated Targeted Gene Regulation.

Moreno, Ana M; Fu, Xin; Zhu, Jie; Katrekar, Dhruva; Shih, Yu-Ru V; Marlett, John; Cabotaje, Jessica; Tat, Jasmine; Naughton, John; Lisowski, Leszek; Varghese, Shyni; Zhang, Kang; Mali, Prashant.

Mol Ther ; 26(7): 1818-1827, 2018 07 05.

Artigo em Inglês | MEDLINE | ID: mdl-29754775

18.

Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach.

Chari, Raj; Mali, Prashant; Moosburner, Mark; Church, George M.

Nat Methods ; 12(9): 823-6, 2015 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-26167643

19.

Multi-kilobase homozygous targeted gene replacement in human induced pluripotent stem cells.

Byrne, Susan M; Ortiz, Luis; Mali, Prashant; Aach, John; Church, George M.

Nucleic Acids Res ; 43(3): e21, 2015 Feb 18.

Artigo em Inglês | MEDLINE | ID: mdl-25414332

20.

Cas9 as a versatile tool for engineering biology.

Mali, Prashant; Esvelt, Kevin M; Church, George M.

Nat Methods ; 10(10): 957-63, 2013 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-24076990

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